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师资队伍
赵春燕
职务/职称:教授/ 博导
研 究 所:药物化学研究所
联系电话:
电子邮件:zhaochy07@lzu.edu.cn
办 公 室:
  • 个人简介
  • 研究成果
  • 研究项目
  • 【基本情况】
      1997. 09- 2001. 06: 兰州大学化学化工学院应用化学专业  学士
      2001. 09 -2006. 06: 兰州大学化学化工学院分析化学专业  博士
      2006. 09 - 2007.08: 意大利 “Mario Negri” Institute 博士后
      2007.08 - 2013.09:yb亚博网站 副教授
      2013.09-现在:yb亚博网站 教授
    【研究方向】
      分子-蛋白质之间相互作用研究;分子毒性/活性作用机制的化学生物学研究
    【主讲课程】
      数理统计学,药物设计学
    【获奖情况】

  • [1] C. Y. Zhao, R. S. Zhang, H. X. Liu, C. X. Xue, S. G. Zhao, X. F. Zhou, M. C. Liu, B.T.Fan. Diagnosing anorexia based on partial least squares, back propagation neural network, and support vector machines. J Chem Inf Comput Sci, 2004, 44, 2040-2046.
    [2] C. Y. Zhao, R. S. Zhang, H. X. Zhang, C. X. Xue, H. X. Liu, M. C. Liu, Z. D. Hu, B. T. Fan. QSAR study of natural, synthetic, and environmental endocrine disrupting compounds for binding to the androgen receptor. SAR &QSAR Environ Res, 2005, 16, 349-367.
    [3] C. Y. Zhao, H. X. Zhang, X. Y. Zhang,  R. S. Zhang, F. Luan, M. C. Liu, Z. D. Hu, B.T. Fan. Prediction of milk-to-plasma drug concentration (M/P) ratio using support vector machine (SVM) method. Pharm Res, 2006, 23, 41-48.
    [4] C. Y. Zhao, H.X. Zhang, X. Y. Zhang, M.C. Liu, Z.D. Hu, B.T. Fan. Application of support vector machine (SVM) for prediction toxic activity of different data sets. Toxicology. 2006, 217, 105-119
    [5] C. Y. Zhao, Y. Zhu, H. X. Zhang, M. C. Liu, B. T. Fan. Accurate prediction of the folding rate for two-state proteins based on amino acid sequences. QSAR &Comb Sci, 2007, 26, 307-316. 
    [6] C. Y. Zhao, H. X. Zhang, F. Luan, R. S. hang, M. C. Liu, Z. D. Hu, B. T. Fan.  QSAR method for prediction of protein-peptide binding affinity: application to MHC lass I molecule HLA-A*0201. J Mol Graph Model, 2007, 26, 246-254.
    [7] C. Y. Zhao, Boriani E., Chana A. Roncaglioni A., Benfenati E. A new hybrid system of QSAR models for predicting bioconcentration factors (BCF). Chemosphere, 2008, 73, 1701–1707.
    [8] J. H. Wu, X. Li, W. D. Wei, Q. J. Xie, Y. Q. Liu, C. Y. Zhao*. Quantitative structure activity relationship (QSAR) approach to multiple drug resistance (MDR) modulators based on combined hybrid system. QSAR &Comb Sci, 2009, 28,933-1077.
    [9] T. Chen, S. Xu, T. Zhao, L. Zhu, D. F. Wei, Y. Y. Li, H. X. Zhang*, C. Y. Zhao*. Gold Nanocluster-Conjugated Amphiphilic Block Copolymer for Tumor-Targeted Drug Delivery. Appl. Mater. Interfaces. 2012, 4, 5766?5774
    [10] Yinqian Liu,Dongfeng Wei,Yonglong Zhao,Weidong Cheng,Yan Lu,Yaqiong Ma,Xin Li,Chao Han,Yanxia Wei,Huiming Cao,Chunyan Zhao(*),Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.,Bioorgan Med Chem,2012,20:6285~6295
    [11] Chao Han,Senbiao Fang,Huiming Cao,Yan Lu,Yaqiong Ma,Dongfeng Wei,Xin Li,Chunyan Zhao(*),Molecular interaction of PCB153 to human serum albumin: Insights from spectroscopic and molecular modeling studies,J Hazard Mater,2013,248– 249:313~321
    [12] Yaqiong Ma,Senbiao Fang,Huanhuan Li,Chao Han,Yan Lu,Yonglong Zhao,Yinqian Liu,Chunyan Zhao(*),Biological Evaluation and Molecular Modelling Study of Podophyllotoxin Derivatives as Potent Inhibitors of Tubulin Polymerization.,Chem Biol Drug Des.,2013,82:12~21
    [13] Senbiao Fang,Huanhuan Li,Tao Liu,Hongxia Xuan,Xin Li,Chunyan Zhao(*),Molecular interaction of PCB180 to human serum albumin: insights from spectroscopic and molecular modelling studies,J Mol Model,2014,20:1~10
    [14] Huanhuan Li,Tao Liu,Hongxia Xuan,Senbiao Fang,Chunyan Zhao(*),A combination of pharmacophore modeling, virtual screening, and molecular docking studies for a diverse set of colchicine site inhibitors.,Med Chem Res,2014,23:4713~4723
    [15] Huanhuan Li,Tao Liu,Hongxia Xuan,Senbiao Fang,Chunyan Zhao(*),A combination of pharmacophore modeling, virtual screening, and molecular docking studies for a diverse set of colchicine site inhibitors,Med Chem Res,2014,23:4713~4723
    [16] Yaquan Liu,Fang Tian,Dejuan Zhi,Haiqing Wang,Chunyan Zhao(*),Hongyu Li,Novel thrombopoietin mimetic peptides bind c-Mpl receptor: Synthesis,biological evaluation and molecular modeling,Bioorgan Med Chem,2017,25:1113~1121

  • 【1】 国家自然科学基金青年项目、21207056、基于分子模拟和体外定点突变技术的单核苷酸多态性核受体与类固醇类内分泌干扰物作用的分子机制研究、2013/01-2015/12、25万元、已结题、主持   
    【2】甘肃省科技厅国际合作项目、1104WCGA187、环境内分泌干扰物分子印迹聚合物的分子模拟和设计、2011/10-2014/10、10万元、已结题、主持
    【3】国家自然科学基金青年项目、31000017、H2O2参与的细菌间体在细胞分裂与细胞损伤中的功能及其分子机制研究、2011/01-2013/12、22万元、已结题、参与
    【4】中央高校基本科研业务费专项资金、非类固醇类T877突变型雄激素受体拮抗剂的分子设计和合成、2010/03-2012/03、8万元、已结题、主持
    【5】甘肃省自然基金项目、099RJYA008、中药墓头回治疗白血病的分子对接和蛋白质组学研究、2009/12-2011/12、2万元、已结题、主持
    【6】环境化学与生态毒理学国家重点实验室开放基金、KF2008-17、分子模拟与光谱法研究环境内分泌干扰物与其受体的结合模式、2008/11-2010/11、10万元、已结题、主持
    【7】自然基金重点项目、90912003、网络环境下抗禽流感病毒H5N1药物的大规模虚拟筛选研究,2009/01-2010/12、110万元、已结题、参与

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