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师资队伍
王 震
职务/职称:三级教授/博导
研 究 所:药物化学研究所
联系电话:
电子邮件:zhenw@lzu.edu.cn
办 公 室:勤博楼3014室
  • 个人简介
  • 研究成果
  • 研究项目
  • 【基本情况】     

    王震,1984年生,甘肃会宁人,博士,三级教授,博士生导师,目前在yb亚博网站工作。九三学社社员,甘肃省领军人才,甘肃省科技专家库收录专家,兰州大学“萃英学者”特聘教授,兰州大学创新创业教育先进个人,兰州大学硕士/本科毕业论文优秀指导教师。20066月毕业于兰州大学化学化工学院,获学士学位;20099月至20127月师从上海有机化学研究所李昂研究员,获硕士学位;201210月至201510月就读于东京大学yb亚博网站,师从Motomu Kanai教授,获博士学位。截至目前,王震教授主持科研项目多项,已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Catalysis , Eur. J. Med. Chem.,等国际一流期刊上发表SCI论文40余篇。目前课题组有教授2名,讲师1名,博士生8名,硕士生19名,本科生若干名。兼任全国青年联合会第十二届委员、中国青年科技工作者协会第六届理事、甘肃省青年联合会第十届常委、甘肃欧美同学会常务理事和兰州市九三学社监察委员会委员。受中央统战部邀请参加新中国成立70周年阅兵观礼。

    课题组主页:http://zhenwanggroup.lzu.edu.cn/index.html

    【研究方向】

    活性天然产物全合成,药物化学研究。

    【主讲课程】

    《药物化学》《药物化学实验》

    【获奖情况】

    2019 甘肃省领军人才

    2019 甘肃省科技专家库收录专家

    2019 兰州大学萃英学者特聘教授

    2019 兰州大学硕士学位毕业论文优秀指导教师

    2019 兰州大学本科毕业论文(设计)及临床毕业实习优秀指导教师

    2017 O一七年挑战杯兰州大学课外学术科技作品竞赛优秀指导教师

    2017 O一六年兰州大学大学生创新创业行动计划优秀指导教师

    2016 兰州大学创新创业教育先进个人


     

  • 【代表性研究成果(第一作者/通讯作者)】

        1.Wang, Z.; Kuninobu, Y.,* and Kanai, M.* “Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C–H Bond Activation.”J. Am. Chem. Soc. 2015, 137, 6140-6143. [JACS Most Read top 5 Articles in May and June. 2015].

        2.Bian, M.;# Wang, Z.;# Xiong, X.; Sun, Y.; Matera, C.; Nicolaou, K. C.* and Li, A.* “Total Syntheses of Anominine and Tubingensin A.” J. Am. Chem. Soc. 2012, 134, 8078-8081. [JACS Most Read Articles in 12 months (08/2011-07/2012); highlighted in Synfacts 2012, 8, 814 and Organic Chemistry Portal].

        3.Wang, Z.; Ni, J.; Kuninobu, Y.* and Kanai, M.* “Copper-Catalyzed Intramolecular C(sp3)-H and C(sp2)-H Amidation by Oxidative Cyclization.” Angew. Chem. Int. Ed. 2014, 53, 3496-3499, [highlighted in Synfacts 2014, 10, 0570].

        4.Zou, J. X.;# Chen, J. H.;# Shi, T.; # Hou, Y. S.; Cao, F.; Wang, Y. Q.; Wang, X. D.; Jia, Z.; Zhao, Q. Y.; and Wang, Z.*Phthalimide-Carried Disulfur Transfer to Synthesize Unsymmetrical Disulfanes via Copper Catalysis.ACS catalysis. 2019, 11426-11430.

        5.Wang, Y. Q.;# Deng, J. D.;# Chen, J. H.; Cao, F.; Hou, Y. S.; Yang, Y. H.; Deng, X. M.; Yang, J. R.; Wu, L. X.; Shao, X. F.; Shi, T.* and Wang, Z.*Dechalcogenization of Aryl Dichalcogenides To Synthesize Aryl Chalcogenides via Copper CatalysisACS catalysis. 2020, 2707-2712.

        6.Wang, Z.; Kuninobu, Y.* and Kanai, M.*“Copper-Mediated Direct C(sp3)−H and C(sp2)−H Acetoxylation.” Org. Lett. 2014, 16, 4790-4793. [highlighted in Synfacts, 2014, 10, 1310].

        7.Hou, Y. S.;# Shi, T.;# Yang, Y. H.; Fan, X. H.; Chen, J. H.; Cao, F. and Wang Z.* “Asymmetric Total Syntheses and Biological Studies of Tuberostemoamide and Sessilifoliamide A” Org. Lett. 2019, 21, 2952-2956.

        8.Jiang, Y.; Deng, J. D.; Wang, H. H.; Zou, J. X.; Wang, Y. Q.; Chen, J. H.; Zhu, L. Q.; Zhang, H. H.; Peng,X.* and Wang, Z.* “Direct Access to α-Sulfenylated Amides/Esters via Sequential Oxidative Sulfenylation and C-C Bond Cleavage of 3-Oxobutyric Amides/Esters.” Chem. Commun. 2018, 54, 802-805.

        9.Zhang, H. H.; Wang, Y. Q.; Huang, L. T.; Zhu, L. Q.; Feng, Y. Y.; Lu, Y. M.; Zhao, Q. Y.; Wang, X. Q.* and Wang, Z.*“NaI-mediated divergent synthesis of isatins and isoindigoes: a new protocol enabled by anoxidation relay strategy.” Chem. Commun.2018, 54, 8265-8268.

        10.Deng, J. D.; Lei, S.; Jiang, Y.; Zhang, H. H.; Hu, X. L.; Wen, H. X.; Tan, W.* and Wang, Z.* “A Concise Synthesis and Biological Study of Evodiamine and Its Analogues.” Chem. Commun. 2019, 55, 3089-3092.

        11.Chen, J. H.; Li, J. F.; Zhu, L. Q.; Peng, X.; Feng, Y. Y.; Lu, Y. M.; Hu, X. L.; Liang, J. P.; Zhao, Q. Y. and Wang, Z.* “Total Synthesis and Structure Revision of Chrysamide B.” Org. Chem. Front. 2018, 5, 3402-3405.

         12.Zou, J. X.; Wang, Y. Q.; Huang, L. T.; Jiang, Y.; Chen, J. H.; Zhu, L. Q.; Yang, Y. H.; Feng, Y. Y.; Peng, X.* and Wang, Z.* “One pot preparation of α-dithioacetal/α-diselenoacetal amides via a dual-C–S/C–Se bond formation and C–C bond cleavage cascade of 3-oxo-butanamides.” Org. Chem. Front. 2018. 5, 2317-2321.

        13.Peng, X.; Wang, H. H.; Cao, F.; Zhang, H. H.; Lu, Y. M.; Hu, X. L.; Tan, W.* and Wang, Z.* “TBHP promoted demethylation of α-aminocarbonyl compounds: a concise approach to substituted γ-lactams.” Org. Chem. Front. 2019, 6,1837-1841.

        14.Bai, Z. J.; Zhang, J. L.; Zhang, Q. P.; Zhang, T. F.; Li, J. L.; Zhao, Q. Y.;*Wang, Z.;*He, D.; Cheng, J.; Zhang, J. K. and Liu.B.Synthesis, toxicities and bio-activities of manganese complexes with CO and H2S dual donors” Eur. J. Med. Chem. 2018, 159, 339-356.

        15.Fan X. H.; Li J. F.; Deng X. M.; Lu Y. M.; Feng Y. Y.; Ma S. M.; Wen H. X.; Zhao Q. Y.; Tan W.; Shi T.; * Wang, Z.* Design, synthesis and bioactivity study of N-salicyloyl tryptamine derivatives as multifunctional agents for the treatment of neuroinflammation Eur. J. Med. Chem. 2020, 193, 112217.

        16.Wang, Z.; Kuninobu, Y.* and Kanai, M.* “Copper-catalyzed Intramolecular N−S Bond Formation by Oxidative Dehydrogenative Cyclization.” J. Org. Chem. 2013, 78,7337-7342.

        17.Jiang, Y.; Feng, Y. Y.; Zou, J. X.; Lei, S.; Hu, X. L.; Yin, G. F.; Tan, W. and Wang, Z.* “Brønsted Base-Switched Selective Mono- and Di-thiolation of Benzamides via Copper Catalysis” J. Org. Chem. 2019, 84, 10490.

        18.Jiang, Y.; Zhang, S. Q.; Cao, F.; Zou, J. X.; Yu, J. L.; Shi, B. F.;*Hong, X.* and Wang, Z.* “Unexpected Stability of CO-Coordinated Palladacycle in Bidentate Auxiliary Directed C(sp3)-H Bond Activation: A Combined Experimental and Computational Study.” Organometallics. 2019, 38, 2022-2030.

        19.Wang, H.H.; Shi, T.; Gao W.W.; Wang Y.Q.; Li J.F.; Jiang Y.; Hou Y.S.; Chen C.; Peng X.* and Wang Z.*, “Sodium Iodide (NaI)-Catalyzed Cross-Coupling for C−S Bond Formation via Oxidative Dehydrogenation: Cheap, Direct Access to Unsymmetrical Aryl Sulfides.” Chem. Asian. J. 2017, 12, 2675–2679.

        20.Wang, H.H.; Shi, T.; Gao, W.W.; Zhang, H.H.; Wang, Y.Q.; Li, J.F.; Jiang, Y.; Hou, Y.S.; Chen, J.H.;Peng, X.* and Wang, Z.* “Double 1,4-addition of (thio)salicylamides/thiosalicylic acids with propiolate derivatives: a direct, general synthesis of diverse heterocyclic scaffolds.” Org. Biomol. Chem. 2017, 15, 8013-8017.

        21.Jiang, Y.; Zou, J. X.; Huang, L. T.; Peng, X.; Deng, J. D.; Zhu, L. Q.; Yang, Y. H.; Feng, Y. Y.; Zhang, X. Y.* and Wang, Z.* “KI-catalyzed C–S bond formation via an oxidation relay strategy: efficient access to various α-thio-β-dicarbonyl compounds.” Org. Biomol. Chem. 2018, 16, 1641-1645.

        22.Zou, J. X.; Jiang, Y.; Lei, S.; Yin, G. F.; Hu, X. L.; Zhao, Q. Y.* and Wang, Z.* “Synthesis of α-arylthioacetones using TEMPO as the C3 synthon via a reaction cascade of sequential oxidation, skeletal rearrangement and C–S bond formation.” Org. Biomol. Chem. 2019, 17, 2341-2345.

        23.Bai, Z. J.; Zhang, J. L.; Zhang, Q. P.; Wang, Y. N.; Li, J. L.; Zhao, Q. Y.; * He,D.; Wang, Z.;* Zhang, J. K. and Liu, B.Anti-atherosclerosis effect of H2S donors based on nicotinic acid and chlorfibrate structures. Bioorganic & Medicinal Chemistry. 2019, 27, 3307.

        24.Wang, Y. Q.;# Zou, J. X.;# Wang, H. H.; Peng, X.; Lu, Y. M.; Feng, Y. Y.; Chen, C.; Shi, T.* and Wang, Z.* A Facile Approach to α-Keto Esters via Oxidative Esterification of α-Amino Carbonyl Compounds. Asian J. Org. Chem. 2019, 8, 1354.

        25.Wang, X.D.; Wang, H.H.; Wu, X.; Yu, T. Q.; Gao, W.W.; Shi, T.; Peng, X.; He, D.* and Wang, Z.* “Total Synthesis of (+)-Mintlactone and (–)-Isomintlactone via SmI2-Induced Radical Cyclization.” Synlett. 2017, 28, 1660-1662.

        26.Wang, Z.; Kuninobu, Y.* and Kanai, M.* “Molybdenum-Mediated Desulfurization of Thiols and Disulfides.” Synlett. 2014, 25, 1869–1872.

        27.Yu, T. Q.; Hou, Y. S.; Jiang, Y.; Xu, W. X.; Shi, T.; Wu, X.; Zhang, J. C.; He, D.* and Wang Z.* “KBr-catalyzed N-S bond formation via oxidative dehydrogenation.” Tetrahedron Lett. 2017, 58, 2084-2087.

        28.Lian, Y.; Zhou, X.; Guo, J. Z.; Zhang, M.; Jiang, H. G.; Fu, C. Q.; Fu, Y. X.; Shi, Z. W.; Liu, Y.; Xin, Z. J.; Lu, X. H.; Liang, J. P.; Hao, B. C.; Li, X. H.; Wang, Z. *Breeding of new Artemisia annua variety "Kehao No.1". China Journal of Chinese Materia Medica. 2019.

     

     

     

     

  •     1.2020年,甘肃省极端环境微生物资源与工程重点实验室开放基金项目,深海天然产物Chrysamide B衍生物的设计合成及其抗胃癌活性和作用机制研究,负责人

        2.2019年,“中央高校基本科研业务费专项资金”科研创新团队建设项目,lzujbky-2019-ct08,新型含硫药物的设计合成与抗炎/抗肿瘤活性评价,负责人

        3.2019年,青海省自然科学基金面上项目,2019-ZJ-907,尼泊尔黄堇抗胃溃疡机制及活性单体的分离合成研究,主要参与者

        4.2016年,中央高校基本科研业务费lzujbky-2016-153,金属钯催化的碳氢键活化和环氧乙烷类化合物的偶联新反应开发和应用,负责人

       5.2016年,甘肃省留学人员科技活动择优资助项目,20161228,具有抗癌活性的Duocarmycin家族天然产物的全合成研究,负责人

       6.2015年,兰州大学科研启动经费项目

     

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