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王 震
研 究 所:药物化学研究所
办 公 室:勤博楼3014室
  • 个人简介
  • 研究成果
  • 研究项目
  • 【基本情况】     

    王震,1984年生,甘肃会宁人,博士,三级教授,博士生导师,目前在yb亚博网站工作。九三学社社员,甘肃省领军人才,甘肃省科技专家库收录专家,兰州大学“萃英学者”特聘教授,兰州大学创新创业教育先进个人,兰州大学硕士/本科毕业论文优秀指导教师。20066月毕业于兰州大学化学化工学院,获学士学位;20099月至20127月师从上海有机化学研究所李昂研究员,获硕士学位;201210月至201510月就读于东京大学yb亚博网站,师从Motomu Kanai教授,获博士学位。截至目前,王震教授主持科研项目多项,已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Catalysis , Eur. J. Med. Chem.,等国际一流期刊上发表SCI论文40余篇。目前课题组有教授2名,讲师1名,博士生8名,硕士生19名,本科生若干名。兼任全国青年联合会第十二届委员、中国青年科技工作者协会第六届理事、甘肃省青年联合会第十届常委、甘肃欧美同学会常务理事和兰州市九三学社监察委员会委员。受中央统战部邀请参加新中国成立70周年阅兵观礼。







    2019 甘肃省领军人才

    2019 甘肃省科技专家库收录专家

    2019 兰州大学萃英学者特聘教授

    2019 兰州大学硕士学位毕业论文优秀指导教师

    2019 兰州大学本科毕业论文(设计)及临床毕业实习优秀指导教师

    2017 O一七年挑战杯兰州大学课外学术科技作品竞赛优秀指导教师

    2017 O一六年兰州大学大学生创新创业行动计划优秀指导教师

    2016 兰州大学创新创业教育先进个人


  • 【代表性研究成果(第一作者/通讯作者)】

        1.Wang, Z.; Kuninobu, Y.,* and Kanai, M.* “Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C–H Bond Activation.”J. Am. Chem. Soc. 2015, 137, 6140-6143. [JACS Most Read top 5 Articles in May and June. 2015].

        2.Bian, M.;# Wang, Z.;# Xiong, X.; Sun, Y.; Matera, C.; Nicolaou, K. C.* and Li, A.* “Total Syntheses of Anominine and Tubingensin A.” J. Am. Chem. Soc. 2012, 134, 8078-8081. [JACS Most Read Articles in 12 months (08/2011-07/2012); highlighted in Synfacts 2012, 8, 814 and Organic Chemistry Portal].

        3.Wang, Z.; Ni, J.; Kuninobu, Y.* and Kanai, M.* “Copper-Catalyzed Intramolecular C(sp3)-H and C(sp2)-H Amidation by Oxidative Cyclization.” Angew. Chem. Int. Ed. 2014, 53, 3496-3499, [highlighted in Synfacts 2014, 10, 0570].

        4.Zou, J. X.;# Chen, J. H.;# Shi, T.; # Hou, Y. S.; Cao, F.; Wang, Y. Q.; Wang, X. D.; Jia, Z.; Zhao, Q. Y.; and Wang, Z.*Phthalimide-Carried Disulfur Transfer to Synthesize Unsymmetrical Disulfanes via Copper Catalysis.ACS catalysis. 2019, 11426-11430.

        5.Wang, Y. Q.;# Deng, J. D.;# Chen, J. H.; Cao, F.; Hou, Y. S.; Yang, Y. H.; Deng, X. M.; Yang, J. R.; Wu, L. X.; Shao, X. F.; Shi, T.* and Wang, Z.*Dechalcogenization of Aryl Dichalcogenides To Synthesize Aryl Chalcogenides via Copper CatalysisACS catalysis. 2020, 2707-2712.

        6.Wang, Z.; Kuninobu, Y.* and Kanai, M.*“Copper-Mediated Direct C(sp3)−H and C(sp2)−H Acetoxylation.” Org. Lett. 2014, 16, 4790-4793. [highlighted in Synfacts, 2014, 10, 1310].

        7.Hou, Y. S.;# Shi, T.;# Yang, Y. H.; Fan, X. H.; Chen, J. H.; Cao, F. and Wang Z.* “Asymmetric Total Syntheses and Biological Studies of Tuberostemoamide and Sessilifoliamide A” Org. Lett. 2019, 21, 2952-2956.

        8.Jiang, Y.; Deng, J. D.; Wang, H. H.; Zou, J. X.; Wang, Y. Q.; Chen, J. H.; Zhu, L. Q.; Zhang, H. H.; Peng,X.* and Wang, Z.* “Direct Access to α-Sulfenylated Amides/Esters via Sequential Oxidative Sulfenylation and C-C Bond Cleavage of 3-Oxobutyric Amides/Esters.” Chem. Commun. 2018, 54, 802-805.

        9.Zhang, H. H.; Wang, Y. Q.; Huang, L. T.; Zhu, L. Q.; Feng, Y. Y.; Lu, Y. M.; Zhao, Q. Y.; Wang, X. Q.* and Wang, Z.*“NaI-mediated divergent synthesis of isatins and isoindigoes: a new protocol enabled by anoxidation relay strategy.” Chem. Commun.2018, 54, 8265-8268.

        10.Deng, J. D.; Lei, S.; Jiang, Y.; Zhang, H. H.; Hu, X. L.; Wen, H. X.; Tan, W.* and Wang, Z.* “A Concise Synthesis and Biological Study of Evodiamine and Its Analogues.” Chem. Commun. 2019, 55, 3089-3092.

        11.Chen, J. H.; Li, J. F.; Zhu, L. Q.; Peng, X.; Feng, Y. Y.; Lu, Y. M.; Hu, X. L.; Liang, J. P.; Zhao, Q. Y. and Wang, Z.* “Total Synthesis and Structure Revision of Chrysamide B.” Org. Chem. Front. 2018, 5, 3402-3405.

         12.Zou, J. X.; Wang, Y. Q.; Huang, L. T.; Jiang, Y.; Chen, J. H.; Zhu, L. Q.; Yang, Y. H.; Feng, Y. Y.; Peng, X.* and Wang, Z.* “One pot preparation of α-dithioacetal/α-diselenoacetal amides via a dual-C–S/C–Se bond formation and C–C bond cleavage cascade of 3-oxo-butanamides.” Org. Chem. Front. 2018. 5, 2317-2321.

        13.Peng, X.; Wang, H. H.; Cao, F.; Zhang, H. H.; Lu, Y. M.; Hu, X. L.; Tan, W.* and Wang, Z.* “TBHP promoted demethylation of α-aminocarbonyl compounds: a concise approach to substituted γ-lactams.” Org. Chem. Front. 2019, 6,1837-1841.

        14.Bai, Z. J.; Zhang, J. L.; Zhang, Q. P.; Zhang, T. F.; Li, J. L.; Zhao, Q. Y.;*Wang, Z.;*He, D.; Cheng, J.; Zhang, J. K. and Liu.B.Synthesis, toxicities and bio-activities of manganese complexes with CO and H2S dual donors” Eur. J. Med. Chem. 2018, 159, 339-356.

        15.Fan X. H.; Li J. F.; Deng X. M.; Lu Y. M.; Feng Y. Y.; Ma S. M.; Wen H. X.; Zhao Q. Y.; Tan W.; Shi T.; * Wang, Z.* Design, synthesis and bioactivity study of N-salicyloyl tryptamine derivatives as multifunctional agents for the treatment of neuroinflammation Eur. J. Med. Chem. 2020, 193, 112217.

        16.Wang, Z.; Kuninobu, Y.* and Kanai, M.* “Copper-catalyzed Intramolecular N−S Bond Formation by Oxidative Dehydrogenative Cyclization.” J. Org. Chem. 2013, 78,7337-7342.

        17.Jiang, Y.; Feng, Y. Y.; Zou, J. X.; Lei, S.; Hu, X. L.; Yin, G. F.; Tan, W. and Wang, Z.* “Brønsted Base-Switched Selective Mono- and Di-thiolation of Benzamides via Copper Catalysis” J. Org. Chem. 2019, 84, 10490.

        18.Jiang, Y.; Zhang, S. Q.; Cao, F.; Zou, J. X.; Yu, J. L.; Shi, B. F.;*Hong, X.* and Wang, Z.* “Unexpected Stability of CO-Coordinated Palladacycle in Bidentate Auxiliary Directed C(sp3)-H Bond Activation: A Combined Experimental and Computational Study.” Organometallics. 2019, 38, 2022-2030.

        19.Wang, H.H.; Shi, T.; Gao W.W.; Wang Y.Q.; Li J.F.; Jiang Y.; Hou Y.S.; Chen C.; Peng X.* and Wang Z.*, “Sodium Iodide (NaI)-Catalyzed Cross-Coupling for C−S Bond Formation via Oxidative Dehydrogenation: Cheap, Direct Access to Unsymmetrical Aryl Sulfides.” Chem. Asian. J. 2017, 12, 2675–2679.

        20.Wang, H.H.; Shi, T.; Gao, W.W.; Zhang, H.H.; Wang, Y.Q.; Li, J.F.; Jiang, Y.; Hou, Y.S.; Chen, J.H.;Peng, X.* and Wang, Z.* “Double 1,4-addition of (thio)salicylamides/thiosalicylic acids with propiolate derivatives: a direct, general synthesis of diverse heterocyclic scaffolds.” Org. Biomol. Chem. 2017, 15, 8013-8017.

        21.Jiang, Y.; Zou, J. X.; Huang, L. T.; Peng, X.; Deng, J. D.; Zhu, L. Q.; Yang, Y. H.; Feng, Y. Y.; Zhang, X. Y.* and Wang, Z.* “KI-catalyzed C–S bond formation via an oxidation relay strategy: efficient access to various α-thio-β-dicarbonyl compounds.” Org. Biomol. Chem. 2018, 16, 1641-1645.

        22.Zou, J. X.; Jiang, Y.; Lei, S.; Yin, G. F.; Hu, X. L.; Zhao, Q. Y.* and Wang, Z.* “Synthesis of α-arylthioacetones using TEMPO as the C3 synthon via a reaction cascade of sequential oxidation, skeletal rearrangement and C–S bond formation.” Org. Biomol. Chem. 2019, 17, 2341-2345.

        23.Bai, Z. J.; Zhang, J. L.; Zhang, Q. P.; Wang, Y. N.; Li, J. L.; Zhao, Q. Y.; * He,D.; Wang, Z.;* Zhang, J. K. and Liu, B.Anti-atherosclerosis effect of H2S donors based on nicotinic acid and chlorfibrate structures. Bioorganic & Medicinal Chemistry. 2019, 27, 3307.

        24.Wang, Y. Q.;# Zou, J. X.;# Wang, H. H.; Peng, X.; Lu, Y. M.; Feng, Y. Y.; Chen, C.; Shi, T.* and Wang, Z.* A Facile Approach to α-Keto Esters via Oxidative Esterification of α-Amino Carbonyl Compounds. Asian J. Org. Chem. 2019, 8, 1354.

        25.Wang, X.D.; Wang, H.H.; Wu, X.; Yu, T. Q.; Gao, W.W.; Shi, T.; Peng, X.; He, D.* and Wang, Z.* “Total Synthesis of (+)-Mintlactone and (–)-Isomintlactone via SmI2-Induced Radical Cyclization.” Synlett. 2017, 28, 1660-1662.

        26.Wang, Z.; Kuninobu, Y.* and Kanai, M.* “Molybdenum-Mediated Desulfurization of Thiols and Disulfides.” Synlett. 2014, 25, 1869–1872.

        27.Yu, T. Q.; Hou, Y. S.; Jiang, Y.; Xu, W. X.; Shi, T.; Wu, X.; Zhang, J. C.; He, D.* and Wang Z.* “KBr-catalyzed N-S bond formation via oxidative dehydrogenation.” Tetrahedron Lett. 2017, 58, 2084-2087.

        28.Lian, Y.; Zhou, X.; Guo, J. Z.; Zhang, M.; Jiang, H. G.; Fu, C. Q.; Fu, Y. X.; Shi, Z. W.; Liu, Y.; Xin, Z. J.; Lu, X. H.; Liang, J. P.; Hao, B. C.; Li, X. H.; Wang, Z. *Breeding of new Artemisia annua variety "Kehao No.1". China Journal of Chinese Materia Medica. 2019.





  •     1.2020年,甘肃省极端环境微生物资源与工程重点实验室开放基金项目,深海天然产物Chrysamide B衍生物的设计合成及其抗胃癌活性和作用机制研究,负责人







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