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师资队伍
王少华
职务/职称:院长/三级教授/博导
研 究 所:药物化学研究所
联系电话:
电子邮件:wangshh@lzu.edu.cn
办 公 室:
  • 个人简介
  • 研究成果
  • 研究项目
  • 【基本情况】
      yb亚博网站药物化学研究所教师。2001年、2006年在兰州大学化学与化工学院分别获得学士及博士学位,导师涂永强教授;2006-2011年在美国梅奥医学中心做博士后研究;2011年至今在yb亚博网站工作。
    【研究方向】
      主要针对具有生物(药物)活性的小分子的设计与合成,以及天然药物分子全合成和相关合成方法学研究。
    【主讲课程】
      本科生《仪器分析》,《化学制药工艺学》,研究生《专业英语》
    【获奖情况】
      2015年教育部自然科学一等奖(第四完成人)
           2015年兰州大学医学院本科实践教学优秀指导教师
           2016年国家自然科学二等奖(第四完成人)
           2016年兰州大学本科毕业论文优秀指导教师
           2016年兰州大学创新创业行动计划“优秀指导教师”
           2017年甘肃省青年教师成才奖
           2017年兰州大学青年五四奖章
           2017年兰州大学本科毕业论文优秀指导教师
           2018年“长江学者奖励计划”青年学者
           2019年兰州大学隆基教学新秀奖
           2019年兰州大学本科毕业论文优秀指导教师
           2020年江苏省双创人才

  •   1.Hou, S.-H.; Tu, Y.-Q.*; Liu, L.; Zhang, F.-M.; Wang, S.-H.*; Zhang, X.-M., Divergent and Efficient Syntheses of the Lycopodium Alkaloids (−)-Lycojaponicumin C, (−)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine. Angewandte Chemie International Edition 2013, 52 (43), 11373-11376.

      2.Chen, Z.-M.; Zhang, Z.; Tu, Y.-Q.*; Xu, M.-H.; Zhang, F.-M.; Li, C.-C.; Wang, S.-H.*, A Mn(iii)/TEMPO-co-mediated tandem azidation-1,2-carbon migration reaction of allylic silyl ethers. Chemical Communications 2014, 50 (74), 10805-10808.

      3.Peng Rui, Y. B., Chen Zhimin, Xu Li, Wang Shaohua*, Copper-Catalyzed Trifluoromethylation of Enol Ether. Chinese Journal of Organic Chemistry 2014, 34 (5), 980-984.

      4.Tian, J.-M.; Zhao, X.; Tu, Y.-Q.*; Gong, W.; Zhang, F.-M.; Zhang, S.-Y.; Wang, S.-H.*, A Synthetic Approach for Constructing the 3/6/6/5-Fused Tetracyclic Skeleton of Tenuipesine A. Chemistry – An Asian Journal 2014, 9 (3), 724-727.

      5.Wang, S. H.; Tu, Y. Q.; Tang, M., 3.16 The Semipinacol Rearrangements. In Comprehensive Organic Synthesis II (Second Edition), Knochel, P., Ed. Elsevier: Amsterdam, 2014; pp 795-852.

      6.Wang, S.-H.; Li, B.-S.; Tu, Y.-Q.*, Catalytic asymmetric semipinacol rearrangements. Chemical Communications 2014, 50 (19), 2393-2408.

      7.Xu, L.; Mou, X.-Q.; Chen, Z.-M.; Wang, S.-H.*, Copper-catalyzed intermolecular azidocyanation of aryl alkenes. Chemical Communications 2014, 50 (73), 10676-10679.

      8.Mou, X.-Q.; Xu, L.; Wang, S.-H.*; Yang, C., Copper-catalyzed dicyanation of N,N-disubstituted formamide. Tetrahedron Letters 2015, 56 (21), 2820-2822.

      9.Mou, X.-Q.; Xu, Z.-L.; Wang, S.-H.*; Zhu, D.-Y.; Wang, J.; Bao, W.; Zhou, S.-J.; Yang, C.; Zhang, D., An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole. Chemical Communications 2015, 51 (60), 12064-12067.

      10.Yang, C.; Xu, Z.-L.; Shao, H.; Mou, X.-Q.; Wang, J.; Wang, S.-H.*, A Tin(IV) Chloride Promoted Tandem C?O Bond Cleavage/Nazarov Cyclization/Nucleophilic Addition Reaction of 1,1-Disubstituted Allylic Ethers toward the Synthesis of Multisubstituted Indenes. Organic Letters 2015, 17 (21), 5288-5291.

      11.Zhu, D.-Y.; Xu, M.-H.; Tu, Y.-Q.*; Zhang, F.-M.; Wang, S.-H.*, Catalytic Asymmetric Construction of α-Quaternary Cyclopentanones and Its Application to the Syntheses of (−)-1,14-Herbertenediol and (−)-Aphanorphine. Chemistry – A European Journal 2015, 21 (44), 15502-15505.

      12.Zhu, D.-Y.; Zhang, Z.; Mou, X.-Q.; Tu, Y.-Q.*; Zhang, F.-M.; Peng, J.-B.; Wang, S.-H.*; Zhang, S.-Y., Gold(I)/Copper(II)-Cocatalyzed Tandem Cyclization/Semipinacol Reaction: Construction of 6-Aza/Oxa-Spiro[4.5]decane Skeletons and Formal Synthesis of (±)-Halichlorine. Advanced Synthesis & Catalysis 2015, 357 (4), 747-752.

      13.徐力, 王., 李辉, 阿托伐他汀的合成. 有机化学 2015, 35 (7), 1559-1564.

      14.Dou, Q.-Y.; Tu, Y.-Q.*; Zhang, Y.; Tian, J.-M.; Zhang, F.-M.; Wang, S.-H.*, Spiro-Pyrrolidine-Catalyzed Asymmetric Conjugate Addition of Hydroxylamine to Enals and 2,4-Dienals. Advanced Synthesis & Catalysis 2016, 358, 874.

      15.Mou, X.-Q.; Xu, Z.-L.; Xu, L.; Wang, S.-H.*; Zhang, B.-H.; Zhang, D.; Wang, J.; Liu, W.-T.; Bao, W., The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction. Organic Letters 2016, 18 (16), 4032-4035.

      16.Wang, J.; Mou, X.-Q.; Zhang, B.-H.; Liu, W.-T.; Yang, C.; Xu, L.; Xu, Z.-L.; Wang, S.-H.*, A metal-free addition/dearomatizationΓÇôcyclization/decarboxylation cascade of aryl 3-arylpropiolate toward the synthesis of 1,1-diaryl-2-alkyl-substituted ethylenes. Tetrahedron Letters 2016, 57 (11), 1239-1242.

      17.Xu, X.-T.*; Mou, X.-Q.; Xi, Q.-M.; Liu, W.-T.; Liu, W.-F.; Sheng, Z.-J.; Zheng, X.; Zhang, K.; Du, Z.-Y.; Zhao, S.-Q.; Wang, S.-H.*, Anti-inflammatory activity effect of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole on TPA-induced skin inflammation in mice. Bioorganic & Medicinal Chemistry Letters 2016, 26 (21), 5334-5339.

      18.Liu, W.-T.; Xu, Z.-L.; Mou, X.-Q.; Zhang, B.-H.; Bao, W.; Wang, S.-H.*; Lee, D.; Lei, L.-S.; Zhang, K., The synthesis of cycloalka[b]furans via an Au(i)-catalyzed tandem reaction of 3-yne-1,2-diols. Organic & Biomolecular Chemistry 2017, 15 (30), 6333-6337.

      19.Zhang, B.-H.; Lei, L.-S.; Liu, S.-Z.; Mou, X.-Q.; Liu, W.-T.; Wang, S.-H.*; Wang, J.; Bao, W.; Zhang, K., Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles. Chemical Communications 2017, 53 (61), 8545-8548.

      20.Zhang, X.-M.; Tu, Y.-Q.*; Zhang, F.-M.; Chen, Z.-H.; Wang, S.-H.*, Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis. Chemical Society Reviews 2017, 46 (8), 2272-2305.

      21.Shao, H.; Bao, W.; Jing, Z.-R.; Wang, Y.-P.; Zhang, F.-M.; Wang, S.-H.*; Tu, Y.-Q.*, Construction of the [6,5,7,5] Tetracyclic Core of Calyciphylline A Type Alkaloids via a Tandem Semipinacol Rearrangement/Nicholas Reaction. Organic Letters 2017, 19 (17), 4648-4651.

      22.Liu, L.; Cheng, H.-L.; Ma, W.-Q.; Hou, S.-H.; Tu, Y.-Q.*; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H.*, Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C-H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization. Chemical Communications 2018, 54 (2), 196-199.

      23.吕卉, 徐., 黄丹颖, 吴盼盼, 盛钊君, 刘文锋, 李冬利, Njud S. Alharbi, 张焜, 王少华, 内质网荧光探针研究进展. 有机化学 2018, 38 (12), 3165-3175

      24.Bao, W.; Wang, J.-Q.; Xu, X.-T.; Zhang, B.-H.; Liu, W.-T.; Lei, L.-S.; Liang, H.; Zhang, K.; Wang, S.-H.*, Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines. Chemical Communications 2018, 54 (59), 8194-8197.

      25.Liu, L.; Lei, L.-S.; Zhan, Z.-S.; Liu, S.-Z.; Wang, Y.-X.; Tu, Y.-Q.*; Zhang, F.-M.; Zhang, X.-M.; Ma, A.-J.; Wang, S.-H.*, A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] skeleton. Chem. Commun. 2019, 55 (26), 3789-3792[1]

      26.Lei, L.-S.; Xue, C.-G.; Xu, X.-T.; Jin, D.-P.; Wang, S.-H.*; Bao, W.; Liang, H.; Zhang, K.; Asiri, A. M., The synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles. Organic & Biomolecular Chemistry 2019, 17 (15), 3723-3726.

      27.Xu, X.; Chen, J.; Lin, Z.; Li, D.; Zhang, K.; Sheng, Z.; Wang, S.*; Zhu, S.; Abdullah M. A. Synthesis and Anti-inflammatory Effects of Oxaprozin-Paeonol Ester[J]. Chinese Journal of Organic Chemistry, 2019, 39(10): 2958-2964.

      28.Zhang, Y.; Zheng, T.-L.; Cheng, F.; Dai, K.-L.; Zhang, K.; Ma, A.-J.; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H.*; Tu, Y.-Q.* Facile access to diverse all-carbon quaternary center containing spirobicycles by exploring a tandem Castro–Stephens coupling/acyloxy shift/cyclization/semipinacol rearrangement sequence. Chemical Science 2020, 11, 3878-3884.

      29.Bao, W.; Gao, Z.-P.; Jin, D.-P.; Xue, C.-G.; Liang, H.; Lei, L.-S.; Xu, X.-T.; Zhang, K.; Wang, S.-H.*, Direct synthesis of 2-substituted benzonitriles via alkylcyanation of arynes with N,N-disubstituted aminomalononitriles. Chem. Commun. 2020, 56 (55), 7641-7644.

      30.Lei, L.-S.; Wang, B.-W.; Jin, D.-P.; Gao, Z.-P.; Huan, L.; Wang, S.-H.*; Xu, X.-T.; Zhang, K.; Zhang, X.-Y.*, Al(Otf)3-Catalyzed Tandem Coupling Reaction between N,N-Disubstituted Aminomalonitriles and Substituted Arenes: a Synthesis of 1-Cyano-bisindolylmethane Analogues≠. Advanced Synthesis & Catalysis 2020, 362 (14), 2870-2875.

      31.Xu, X.-T.; Deng, X.-Y.; Chen, J.; Liang, Q.-M.; Zhang, K.; Li, D.-L.; Wu, P.-P.; Zheng, X.; Zhou, R.-P.; Jiang, Z.-Y.; Ma, A.-J.; Chen, W.-H.*; Wang, S.-H.*, Synthesis and biological evaluation of coumarin derivatives as α-glucosidase inhibitors. European Journal of Medicinal Chemistry 2020, 189, 112013.

      32.Zheng, T.-L.; Zhang, Y.; Gou, A. L.; Cheng, F.; Liu, S.-Z.; Yu, L.*; Cui, M.-Y.; Xu, X.-T.; Zhang, K.; Wang, S.-H.*, Au(I)-Catalyzed Cyclization/Semipinacol Rearrangement Reaction of Allenes to Construct Quaternary Carbon-Containing Scaffolds. Organic Letters 2020, 22 (18), 7073-7077.

      33.Liang, H.; Gou, A.; Gao, Z.; Lei, L.; Wang, B.; Yu, L.*; Xu, X.; Wang, S.*, A New Strategy for the Synthesis of Tertiary Amides via a Copper-Catalyzed Decyanation Reaction of N,N-Disubstituted 2-Aminomalononitriles. Acta Chim. Sinica 2020, 78, 1064.

      34.Wang Shaohua, Z. B., Chen Jie, Zheng Yingying, Feng Na, Ma Aijun, Xu Xuetao, Abdullah M. Asiri, Recent Progress in Synthesis of Polysubstituted Pyrazoles. Chinese Journal of Organic Chemistry 2020, 40 (1), 15-27.

      35.Zheng, T.-L.; Liu, S.-Z.; Huo, C.-Y.; Li, J.; Wang, B.-W.; Jin, D.-P.; Cheng, F.; Chen, X.-M.*, Zhang, X.-M.; Xu, X.-T.; Wang, S.-H.*, Au-Catalyzed 1,3-Acyloxy Migration/Cyclization Cascade: A Direct Strategy toward the Synthesis of Functionalized Abietane-Type Diterpenes. CCS Chem. 2020, 2, 2795-2802.

      36.Liu, S.-Z.; Li, J.; Xue, C.-G.; Xu, X.-T.; Lei, L.-S.; Huo, C.-Y.; Wang, Z.; Wang, S.-H.*, Copper-promoted cyanation of aryl iodides with N,N-dimethyl aminomalononitrile. Tetrahedron Lett. 2021, 65, 152749.

     


  • 【1】国家自然科学基金面上项目,21772071,负责人;
    【2】国家自然科学基金面上项目,21472077,负责人;
    【3】国家自然科学基金青年基金项目,21202073,负责人;
    【4】甘肃省自然科学基金项目,20JR10RA608,负责人;
    【5】国家“重大新药创制”科技重大专项子课题,2012ZX09201-101 -003,参与。

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