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师资队伍
胡芳弟
职务/职称:所长/二级教授/博导
研 究 所:药物分析学研究所
联系电话:
电子邮件:hufd @lzu.edu.cn
办 公 室:勤博楼2013室
  • 个人简介
  • 研究成果
  • 研究项目
  •   【基本情况】

    二级教授,博士生导师,甘肃省“飞天学者”,兰州市中药学科领军人才,甘肃省高校青年成才奖获得者。主要研究方向:中草药化学成分分离分析、体内药物分析、中药质量标准、中药新药及保健食品研发、中药药效物质基础研究及基于中药活性成分及疾病相关生物标志物灵敏测定的传感器研究。2009~2010年美国University of South Alabama访问学者,2012~2014年在上海中医药大学中药研究所从事博士后研究。先后主持或参与完成了国家科技部科技攻关项目利“当归大黄的规范化种植研究”、十二五国家科技支撑计划项目“当归产业化升级示范研究”项目、甘肃省科技支撑计划项目“党参产地加工一体化关键技术研究”项目、国家重要质量标准化研究项目“党参等六种中药材的质量全程控制研究”项目, 甘肃省中医药管理局“甘肃优质道地药材道地性评价方法研究”项目、兰州市创新人才基金项目“甘肃优质道地药材产地加工一体化关键技术研究与示范”和兰州市成果转化项目“甘肃优质道地药材新型饮片的研发”等20余项;获甘肃省科技进步奖二等奖2项,甘肃省科技进步奖三等奖2项,兰州市科技进步奖一等奖2项,兰州市科技发明奖一等奖1项,城关区科技进步奖一等奖1项,甘肃省皇甫谧中医药科技一等奖1项,甘肃省皇甫谧中医药科技三等奖1项。发表学术论文70余篇,其中SCI论文30篇;主编教材2部,授权国家发明专利4项,申请国家发明专利12项

    【研究方向】

    1)中药(天然药物)成分分离分析及中药药效物质基础研究; 

    2)体内药物分析及药代动力学研究;  

    3)中药多糖化学及生物学研究; 

    4)中药新药及中药保健品研发; 

    5)天然药物及生物活性分子生物电化学研究。

    【主讲课程】  

    《天然药物化学》、《现代色谱》、《药学概论》、《体内药物分析》

    【获奖情况】:

    1)兰州大学巾帼标兵(2017);

    2)甘肃省飞天学者(2016); 

    3)甘肃省科技进步二等奖(排名第一,2016); 

    4)甘肃省专利三等奖(排名第一,2015); 

    5)兰州市科技发明一等奖(排名第一,2015); 

    6)城关区科技进步一等奖(排名第一,2015); 

    7)兰州大学隆基教学骨干奖(2013); 

    8)甘肃省科技进步二等奖(排名第二,2012); 

    9)兰州市科技进步一等奖(排名第二,2012)。 

  • 【1】Bolu Sun, Yuqiang Gou, Yuling Ma, Xiaoping Zheng, Ruibin Bai, Ahmed Attia Ahmed Abdelmoaty, Fangdi Hu*, In Investigate electrochemical immunosensor of cortisol based on gold nanoparticles/magnetic functionalized reduced grapheneoxide. Biosensors and Bioelectronics, 2017;88:52-62.

    【2】Pei Zhang, Linhai Hu, Ruibin Bai, Xiaoping Zheng, Yuling Ma, Xia Gao, Bolu Sun, Fangdi Hu?, Structural characterization of a pectic polysaccharide from Codonopsispilosula and its immunomodulatory activities in vivo and in vitro. International Journal of Biological Macromolecules 2017;104:1359–1369.

    【3】 Xiao?Ping Zheng, Fang?Di Hu*, Li Yang, Yu?Ling Ma, Bo?Lu Sun, Chang?Hong Wang Zheng?Tao Wang, The Effects of Different Compatibilities of Qing’e Formula on Scopolamine?induced Learning and Memory Impairment in the Mouse. World J Tradit Chin Med. 2017;(3)3:12-17.

    【4】强思思,高霞,马玉玲,郑晓萍,胡芳弟*,李应东. 基于纹党鲜药材的产地加工炮制一体化技术研究, 中国中医药信息杂志. 2017;23 (1)14-17.

    【5】Bolu Sun, Xiaodan Gou, Ruibin Bai, Ahmed Attia Ahmed Abdelmoaty, Yuling Ma, Xiaoping Zheng, Fangdi Hu*, Direct electrochemistry and electrocatalysis of lobetyolin via magnetic functionalized reduced graphene oxide film fabricated electrochemical sensor. Materials Science and Engineering C.  2017,74: 515–524.

    【6】Xia Gao, Yu-Ling Ma, Pei Zhang, Xiao-Ping Zheng, Bo-Lu Sun and Fang-Di Hu*,Chemical Characteristics Combined with Bioactivity for Comprehensive Evaluation of Tumuxiang Based on HPLC-DAD and Multivariate Statistical Methods, Modern Research on Chinese Materia Medica,2016;2(2):36-47.

    【7】孙伯禄, 苟于强, 马玉玲, 郑晓萍, 胡芳弟* , 基于DNA / Nafion-聚二烯丙基二甲基氯化铵功能化的石墨烯电化学传感器评价阿魏酸及当归水提物抗氧化活性, 分析化学, 2016;44(10):1575-1583.

    【8】Jing An, Fangdi Hu*, Changhong Wang, Zijia Zhang, Li Yang, and Zhengtao Wang Pharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS, Xenobiotica. 2016:1-12. 

    【9】Pei Zhang, Yu-QiangGou, Xia Gao, Rui-Bin Bai, Wen-Xia Chen, Bo-Lu Sun, Fang-Di Hu, Wang-Hong Zhao. The pharmacokinetic study of rutin in rat plasma based on an electrochemically reduced grapheneoxide modified sensor, Journal of Pharmaceutical Analysis. 2016;6(2):80-86.

    【10】张 培,郑晓萍,马玉玲,白瑞斌,胡芳弟*, 党参多糖单糖组成与其对HepG2 细胞毒活性的相关分析,中草药. 2016; 47(15):2684-2692. 

    【11】高霞,张培,强思思,胡林海,胡芳弟*,李应东. 蜜炙纹党的炮制新工艺研究,中国现代应用药.2016;33(5):262-268.

    【12】高霞, 强思思, 郑晓萍, 胡林海, 胡芳弟*, 李应东. 纹党产地初加工工艺的优化,中成药,2016;8(6):1330-1337. 11.

    【13】吴红梅,苟于强,胡林海,胡芳弟*,陈嘉屿,杨春霞,白瑞斌. 纹党参多糖联合环磷酰胺对S180 荷瘤小鼠抗肿瘤增效机制的研究, 2016;29(4):17-21. 

    【14】 Bolu Sun, Yuqiang Gou, Zhiyuan Xu, Xiaoping Zheng, Yuling Ma, Fangdi Hu*, Wanghong Zhao. Protections of bovine serum albumin protein from damage on functionalized graphene-based electrodes by flavonoids. Materials Science and Engineering C, 2016; 62: 197-205.

    【15】Jing An, Fangdi Hu, Changhong Wang, Zijia Zhang, Li Yang, and Zhengtao Wang*. Pharmacokinetics and tissue distribution of five active ingredients of Eucommia cortex in normal and ovariectomized mice by UHPLC-MS/MS. Xenobiotica, 2016 Early Online: 1-12 DOI: 10.3109/00498254.2015.1129470.

    【16】Wenxia Chen, Yuqiang Gou, Jiayu Chen, Hongmei Wu, Fangdi Hu*, Activation of intrinsic apoptotic signaling pathway in A549 cell by a pectin polysaccharide isolated from codonopsis pilosula and its selenized derivative. Journal of carbohydrate Chemistry. DOI 10.1080/ 07328303. 2015. 1095924.

    【17】Fangdi Hu, JingAn, WenLi, Zijia Zhang, Wenxia Chen, Changhong Wang, Zhengtao Wang. UPLC-MS/MS determination and gender-related pharmacokinetic study of five active ingredients in rat plasma after oral administration of Eucommia cortex extract. Journal of Ethnopharmacology. 2015,169:145–155.

    【18】陈嘉屿,胡林海,吴红梅,边向聪,张培,高霞,陈文霞,胡芳弟*,党参多糖对荷瘤小鼠免疫应答及抑瘤作用研究[J]. 中华肿瘤防治杂志,2015;22(17):1357-1362.

    【19】陈文霞,张培,高霞,白瑞斌,胡芳弟*,基于抗肿瘤活性的纹党参多糖硒化工艺研究[J].中成药,2015;37(11):2408-2415.

    【20】Wenxia Chen, Jiayu Chen, Hongmei Wu, Yuqiang Gou, Fangdi Hu*, Optimization of selenylation conditions for a pectic polysaccharideand its structural characteristic. International Journal of Biological Macromolecules.2014;69:244-251.

    【21】Wenxia Chen, Hongmei Wu, Linjie Liu, Pei Zhang, Xia GaO, Fangdi Hu*, Fingerprint Analysis and Peak Pattern Matching of Xiaochaihu Granules at Multi-Wavelength Latin American Journal of Pharmacy.   Lat. Am. J. Pharm. 2014;33 (3): 382-91.

    【22】Linjie Liu, Yuqiang Gou, Xia Gao, Pei Zhang, Fangdi Hu*, .Electrochemically reduced graphene oxide-based electrochemical sensor for the sensitive determination of ferulic acid in A. sinensis and biological samples. Materials Science and Engineering C. (2014),42:227-233.

    【23】 Linjie Liu, Xia Gao, Pei Zhang, Fangdi Hu*, Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor. Journal of Analytical Methods in Chemistry. Volume 2014;9 pages. doi.org / 10.1155/ 2014/ 424790.

    【24】Jing An, Yuqiang Gou, Chunxia Yang, Fangdi Hu*, Chunming Wang,Synthesis of a biocompatible gelatin functionalized graphene nanosheets and its application for drug delivery. Materials Science and Engineering C. 2013;33: 2827–2837.

    【25】Jing An, Jiping Li, Wenxia Chen, Chunxia Yang, Fangdi Hu * and Chunming Wang. Electrochemical study and application on shikonin at poly(diallyldimethylammonium chloride) functionalized graphene sheets modified glass carbon electrode. Chem. Res. Chin. Univ. 2013;4:798-805

    【26】Jing An, Yingyan Bi, ChunxiaYang, Fangdi Hu*, ChunmingWang Electrochemical study and application on rutin at chitosan/graphene films modified glassy carbon electrode. Journal of pharmaceutical analysis. 2013;3(2):106-108.

    【27】Qingliang Feng, Yongling Du, Chao Zhang, Zhixiang Zheng, Fangdi Hu, Zaihua Wang, Chunming Wanga Synthesis of the multi-walled carbon nanotubes-COOH/graphene/goldnanoparticles nanocomposite for simple determination of Bilirubin in humanblood serum. Sensors and Actuators B: Chemical. 2013;185:337-344.

    【28】Zilong Dang, Demei Feng, Xiaohua Liu, Tao Yang, Long Guo, Jin Liang, Jiandi Liang, Fangdi Hu, Fang Cui, Shilan Feng, Structure and antioxidant activity study of sulfated acetamidopolysaccharide from Radix Hedysari. Fitoterapia. 2013;89: 20-32.

    【29】 Chunxia Yang, Yuqiang Gou, Jiayu Chen, Jing An, Wenxia Chen, Fangdi Hu? Structural characterization and antitumor activity of a pecticpolysaccharide from Codonopsis pilosula. Carbohydrate Polymers.2013;98 886-895.

    【30】陈文霞,武静莲,马 东,张 培,高 霞,胡芳弟*, 小柴胡颗粒制剂-药材谱峰匹配指纹图谱研究[J],中草药 Chinese Traditional and Herbal Drugs. 2013;44(22): 3154-3161.

    【31】 杨春霞,胡林海,吴红梅,王东,安婧,胡芳弟*,中心组合设计优化提取文党参多糖及其硒含量的测定[J].西北师范大学学报(自然科学版)2013;49(1):66-71.

    【32】韩菁, 刘新荣, 刘小花,吴红梅, 杨春霞, 安婧, 崔方, 胡芳弟*.丹酚酸B的电化学行为及其测定[J].兰州大学学报(自然科学版),2012;48(1):123-126.

    【33】杨雪梅,杨海红,杨春霞,安 婧,安美霖,胡芳弟*.当归活性成分提取及其复合物栓剂抗炎活性研究[J]. 西北师范大学学报(自然科学版),2012;48(4):71-75.

    【34】 马玉凤,李文,胡芳弟,石义凯,毕映燕,封士兰, LC-MS /MS 测定大鼠血浆中香柑内酯及其药代动力学研究,中国中药杂志,2012;37(3):381-383.

    【35】Yikai Shi, Lianggong Zhao, Xiaohua Liu, Fangdi Hu, Fang Cui, Yingyan Bi, Yufeng Ma,Shilan Feng,Structural characterization of a sulfated glucan isolated from the aqueous extract of Hedysarum polybotrys Hand.-Mazz. Carbohydrate Polymers. 2012;87:160-169.

    【36】 Fangdi Hu, Shilan Feng, Yuqiong Wu,Yingyan Bi, Chunming Wang*. Quantitative analysis of costunolide and dehydrocostuslactone in rat pLasma by ultraperformance liquid chromatography–electrospray ionization–mass spectrometry. Biomed. Chromatogr. 2011;25: 547-554.

  • 【1】中药新药骨健颗粒的提取工艺优化及质量标准研究(合同编号2017620001000602),横向项目,负责人。

    【2】党参增免口服液的工业化研究(2017-4-119),兰州市科技局专利转化项目,负责人。

    【3】甘肃省地方习用药材质量标准提升及产业化应用(17ZD2FA009),甘肃省科技重大专项,兰州大学项目负责人。

    【4】百合鳞茎冻干片及相关健康产品开发研究,横向项目,负责人。

    【5】甘肃党参资源综合开发利用知识产权创造力提升及对策研究(17ZC1LA016),甘肃省科技计划项目,负责人。

    【6】甘肃特色药材新型饮片研发中心(2016-2-8),兰州市成果转化基地项目,负责人。

    【7】大黄等六种药材质量标准研究项目(ZYBZH-Y-GS-10),国家中医药管理局,兰州大学项目负责人。

    【8】甘肃优质道地药材产地加工炮制一体化关键技术研究(2015-RC-118),兰州市人才创新创业项目,负责人。

    【9】党参山楂健脾养胃咀嚼片的研制,兰州市重大科技计划专项目,2015-3-3,30万,主持

    甘肃省中医药管理局科研课题“甘肃党参药材道地性评价方法研究”GZK-2015-19,3万

    【10】纹党参鲜药材产地加工炮制一体化关键技术研究(1504FKCA010),甘肃省科技支撑计划项目,兰州大学负责人。

    【11】“基于药物代谢动力学的青娥方配伍规律研究”(13R21415700;3013M531203);中国博中国博士后基金,上海市博士后基金:负责人。

电话:0931-8915686 地址:兰州市城关区东岗西路199号  陇ICP备10000336号  

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